It derives its name from the nearby Epifanio de los Santos Avenue.

A product of the prior rehabilitation is the station's lower platforms, which are designed only to accommodate older long-distance trains.

Since September 10, 2018, PNR extended the Caloocan Shuttle Line from Dela Rosa to FTI as its new terminus, thus EDSA station is included in the newly extended line.

[1] The station's major landmarks are the Alphaland Southgate Tower and Mall, San Lorenzo Place and Mall, and Studio 300 on Chino Roces Avenue.

EDSA station is accessible by jeepneys plying the Chino Roces Avenue and South Luzon Expressway routes, as well as buses plying the South Luzon Expressway route.