EHD3

This family of four paralogs (EHD1-EHD4) has been implicated in receptor intracellular trafficking, particularly in internalization and recycling to the plasma membrane.

The main functions are the following: The gene that encodes the human EHD3 protein is located in chromosome number 2, most specifically in the 23.1 region.

It can be mainly found in human heart and brain, as well as kidney, ovary and liver.

The lack or malfunction of this protein in the human body can cause some diseases such as heart failure[19] or a depressive disorder.

Women are more propense to depressive disorders and anxiety than men, although the reason is still unknown.

Still, recent studies have shown the direct relation of some genes and their encoded proteins with the disease, including EHD3.

Moreover, EHD3 has growth inhibitory functions and induces a G0/G1 cell cycle arrest and apoptotic death.

Domains of the EHD3 protein . In orange, the EH domain-containing protein N-terminal. In yellow, the dynamin-type G domain. In navy blue, the coiled-coil domain. In green, the ED domain. And in blue, the EF-hand domain.
Post-translational modifications of the EHD3 . In red, acetylations. In pink, cross-links. And in purple, phosphorylations.
EHD3 can be mainly found in human heart and brain, as well as kidney, ovary and liver. [ 15 ]
EHD3 principal mutations .