EIF-2 kinase

eIF-2-alpha kinase is a kinase enzyme that phosphorylates eIF2α.

There are four forms in mammals: [2] These are all responsible for the phosphorylation of the alpha subunit of eIF-2 at serine 51, one of the best-characterized mechanisms for down-regulating protein synthesis in eukaryotes as a part of cellular stress response.

[3]

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Regulation of translation initiation via phosphorylation of Ser51 in eIF2's α-subunit. [ 1 ]