Edward Marcotte is a professor of biochemistry at The University of Texas at Austin, working in genetics, proteomics, and bioinformatics.
In early work, Marcotte and colleagues created the first genome-scale map of functional links among proteins in any complex organism (the yeast Saccharomyces cerevisiae), an approach that allowed them to predict the function to more than half of all uncharacterized yeast proteins.
[3] Marcotte also developed several methods of identifying functional interactions between proteins, including phylogenetic profiling,[4][5][6] Rosetta Stone gene fusion,[7] mRNA coexpression,[3] and mirror tree[8] approaches.
[12] Marcotte and colleagues developed the spotted cell microarray technique for high-throughput measurement of protein expression, subcellular location, and function,[11][13][14][15] developed algorithms for analyzing mass spectrometry data,[16][17][18][19] started an open access database for mass spectrometry proteomics data,[20] and developed the APEX method for absolute protein quantification on a proteome-wide scale.
[21][22] Using APEX, Marcotte and colleagues demonstrated that protein abundance in a lower eukaryote is predominantly determined by mRNA levels, while human protein abundances are determined roughly equally by transcriptional and post-transcriptional regulation.