In 1927, Elder's girls' department was transferred to Seton High School next door.

The school has an Honors Program which provides the top students Advanced Placement courses in Art, Calculus, Chemistry, Computer Science, English, World History, U.S. History, American Government, and Physics.

[1] On June 4, 2005, the Elder varsity baseball team won their record 12th OHSAA Division I State Championship, defeating Toledo Start 3–0.

As of 2006, the Elder baseball program has the most wins (1257-493-4), from 1924 through 2006, and state titles (12) of any school in Ohio.

[10] In addition to baseball, Elder High School has won multiple OHSAA State Championships in several other major sports, including football, basketball, and cross country: Non-OHSAA-sponsored state championships include: Football games are played at "The Pit".