The chancery is located in Omar Ben Al-Khattab Street in Adawi, Damascus.

In January 1992, with the fall of the Soviet Union, it became the de facto embassy of the Russian Federation.

On 21 February 2013, the embassy was attacked as part of a bombing campaign in Damascus.

On 28 December 2016, a mortar round landed in the embassy's courtyard but did not explode.

[2][3] Russia evacuated some of its personnel from the embassy following the fall of the al-Assad regime in December 2024.