[6] In the case of β-glucosidase, two carboxylate residues of glucosides, cellobiose, cellotriose, cellotetraose are involved at the active site.

In humans, tissues within the liver, small intestine, spleen and kidney contain a cytosolic β-glucosidase (CBG) that hydrolyses various β-d-glycosides.

[8] Liposomal β-glucosidase (glucocerebrosidas), found in human lysosomes, plays an important role in the degradation of glycosphingolipids, breaking down glucosylceramide into ceramide and glucose.

[11][12] Bonnethead sharks are found in tropical and subtropical water living in estuaries with muddy or sandy bottoms, rich with seagrass.

In the case of the Christmas Island red crab β-glucosidase not only produces glucose, but also removes cellobiose.

[15] This in turn makes β-glucosidase a very efficient enzyme in not only the digestive tract of the Christmas Island red crab, but other crustaceans as well.

Synonyms, derivatives, and related enzymes include gentiobiase, cellobiase, emulsin,[16] elaterase, aryl-β-glucosidase, β-D-glucosidase, β-glucoside glucohydrolase, arbutinase, amygdalinase, p-nitrophenyl β-glucosidase, primeverosidase, amygdalase, linamarase, salicilinase, and β-1,6-glucosidase.