The organisms most often isolated are believed to be because of compromised abortions, delivery, medical instrumentation, and retention of placental fragments.

[13] There is very uncertain evidence supporting the use of prophylactic antibiotics to prevent endometritis after manual removal of placental in vaginal birth.

Menstruation after acute endometritis is excessive and in uncomplicated cases can resolve after 2 weeks of clindamycin and gentamicin IV antibiotic treatment.

Patients with chronic endometritis may have an underlying cancer of the cervix or endometrium (although infectious cause is more common).

Antibiotic therapy is curative in most cases (depending on underlying cause), with fairly rapid alleviation of symptoms after only 2 to 3 days.

In human medicine, pyometra (also a veterinary condition of significance) is regarded as a form of chronic endometritis seen in elderly women causing stenosis of the cervical os and accumulation of discharges and infection.

Symptom in chronic endometritis is blood stained discharge but in pyometra the patient complaints of lower abdominal pain.

Signs and symptoms include lower abdominal pain (suprapubic), rigors, fever, and the discharge of pus on introduction of a sound into the uterus.