[10] In the 2021 season opener against the Green Bay Packers, McCoy left the game after suffering a calf injury in the first quarter.

On September 8, 2022, McCoy signed a five-year, $63.75 million contract extension with the Saints.

[14] McCoy was selected to replace Frank Ragnow in the 2024 Pro Bowl Games.

[15] McCoy missed seven games in the 2024 season after undergoing surgery for a groin injury.

On December 28, 2024, McCoy was placed on injured reserve with an elbow injury, ending his season.