Although serving ordinarily as a reconnaissance and bombardment role, they also flew as gunships to escort bombing missions.

[1] When the Battle of the Aisne began in April 1917, Escadrille Let 46 was attached to Felix Brocard's Groupe de Combat 12 for the fight.

When their commanding officer, Didier Lecour Grandmaison, his replacement, Marcel Bloch led it as it re-equipped again, this time with Caudron R.XI three seated bombers.

On 12 September 1918, while fighting in the 1er Armee sector, it was awarded its second citation for valor, earning the escadrille the right to the Fourragere of the Croix de Guerre.

On 23 September 1918, the escadrille was assigned to fly as gunships to protect bombing missions, as the Caudron R.XIs mounted five machine guns apiece.