It spent most of its existence as a component of a larger Groupe de Combat involved in offensive operations.

The squadron was credited with a minimum of 40 confirmed aerial victories during the war.

On 17 March 1917, it was one of four squadrons combined into Groupe de Combat 15 in support of IV Armee.

In the latter part of 1917, the squadron re-equipped with SPAD fighters, and renamed Escadrille Spa.78.

[1] Escadrille Spa.78 ended World War I credited with destruction of at least 40 German aircraft, with another 40 claims judged probable victories.