Escadrille Spa.159 was a French fighter squadron supporting VIII Armee during 1918.

Assigned to VIII Armee, they were incorporated into Groupe de Combat 20 in late February.

In May, it replaced its Nieuport fighters with SPAD XIIIs; its unit designation was altered to Escadrille Spa.159.

By war's end, the squadron had been credited with destroying 11 German airplanes and an observation balloon.

This article about a specific French military unit is a stub.