Escadrille Spa80 was a French fighter squadron active during World War I, from 13 December 1916 to 11 November 1918.

Originally created at Lyon-Bron, France on 13 December 1916 as Escadrille N80 because it was equipped with Nieuport XVII fighters, it was attached to V Armee.

Within a week, they were refitted with SPAD fighters, changing their unit designation to Escadrille Spa80.

[1] The Groupe de Combat would support the British Royal Air Force's 3rd Brigade beginning 15 April 1918.

Escadrille Spa80 ended World War I credited with aerial victories over 21 German airplanes and two observation balloons.