The Esino (Italian: [eˈziːno]; Latin: Aesis)[1] is a river in the Marche region of central Italy.

[2] The river flows east past Esanatoglia and curves north by Matelica before crossing the border into the province of Ancona near Cerreto d'Esi.

Since 1995, the area around the Esino has been permitted to produce red and white Italian DOC wines.

Grapes are limited to a harvest yield of 12 tonnes/ha with the finished wines requiring a minimum alcohol level of 10.5%.

Reds are a minimum 60% of Montepulciano and/or Sangiovese, with other local grape varieties permitted to fill out of the rest.