Etoxadrol

Etoxadrol (CL-1848C) is a dissociative anaesthetic drug that has been found to be an NMDA antagonist and produce similar effects to PCP in animals.

[3][4][5] Phenicyclidine (PCP), tenocyclidine (TCP), etoxadrol and its precursor, dexoxadrol have related chemical structures.

Etoxadrol antagonizes the NMDA receptor by binding to the PCP site, located just above the magnesium block in the ion channel.

[9] Despite its anesthetic and analgesic effects, etoxadrol does not interact with benzodiazepine, muscarinic acetylcholine, or mu opioid receptors.

Patients given etoxadrol often reported that they were aware of experiencing pain upon waking from anesthesia, but it did not bother them.

[5] At high enough doses, etoxadrol also exhibits effects on the muscular system such as convulsions or loss of the righting reflex.

Monkeys given extremely high (> 20 mg/kg) doses of etoxadrol died of apparent respiratory failure.

Etoxadrol produces a wide variety of dreams, ranging from pleasant to frightening or aversive.

Phencyclidine (PCP), ketamine, etoxadrol and dexoxadrol all contain phenyl and amino groups, which bind to the PCP site on the NMDA receptor. Tenocyclidine contains a thiophene ring instead, which is bioisosteric with a phenyl ring.
NMDA receptor action in the absence (left) or presence (right) of etoxadrol.