Eudysmic ratio

Eudisimic ratio (ER) reflects the degree of enantioselectivity of the biological systems.

[6] In some cases, the eudysmic ratio is so high, that it is desired to separate out the two enantiomers instead of leaving it as a racemic product.

There are a few examples of chiral drugs where both the enantiomers contribute, in different ways, to the overall desired effect.

A superficial examination of these facts might suggest the marketing of this product as a racemate (1:1 mixture of both enantiomers) to be desirable, since both enantiomers are complementing each other, but for optimal action, the ideal eutomer to distomer ratio for indacrinone has been determined to be 9:1.

One way the eudysmic ratio is computed is by dividing the EC50 or the IC50 of the eutomer by the same measurement of the distomer.