Not long after World War II had broken out, Eugenidis had to move to Egypt where he set up a line providing regular connections between North Africa and South America by steamship.
He established Home Line, based in Genoa, and managed four ocean liners that carried immigrants from Europe to Africa, Australia, the United States and Canada.
In 1954, Spyros Melas wrote of him in Estia newspaper: "He (Eugenios Eugenides) confessed to me once, when I first met him as the General Consul for Finland in his Glyfada villa, that as far back as when seated in the classrooms of Robert College, where he had been an honour student, he had been dreaming of making a fortune, not only just for himself but in order to be able to be of help to others.
He would pay for publications, finance missions, grant scholarships, facilitate journeys ... there was a whole list of poor people he helped and it is from them that the payment of his monthly obligations started."
Συνιστώ εν Αθήναις κατά τούς ορισμούς του Ελληνικου Δικαίου Ίδρυμα υπό το όνομα ΙΔΡΥΜΑ ΕΥΓΕΝΙΔΟΥ, του οποίου σκοπός είναι νά συμβάλη εiς τήν εκπαίδευσιν νέων Ελληνικής ιθαγενείας εν τω επιστημονικώ καί τεχνικώ πεδίωEugenides Foundation was established in 1956 in Athens, Greece.
On 7 June 1965, a grand ceremony in the presence of the country's political and intellectual leadership marked the opening of the building on Syggrou Avenue that was to house it.