Exonuclease VII

The enzyme exodeoxyribonuclease VII (EC 3.1.11.6, Escherichia coli exonuclease VII, E. coli exonuclease VII, endodeoxyribonuclease VII, exodeoxyribonuclease VII) is a bacterial exonuclease enzyme.

[1][2] It is composed of two nonidentical subunits; one large subunit and 4 small ones.

[3] that catalyses exonucleolytic cleavage in either 5′- to 3′- or 3′- to 5′-direction to yield nucleoside 5′-phosphates.

The large subunit also contains an N-terminal OB-fold domain that binds to nucleic acids.