[8] Ryzhikov and Kud-Sverchkov performed a spacewalk on 18 November 2020 to conduct initial preparations for the replacement of the Pirs docking compartment by the Nauka laboratory module, which lasted 6 hours and 48 minutes.

The 27 January spacewalk, begun at 12:28 UTC and lasting 6 hours and 56 minutes, was conducted by Hopkins and Glover to install a Ka band antenna on Columbus in preparation for Bartolomeo's activation, replace a pin on the Quest Joint Airlock, and remove a grapple fixture on the P4 Truss for the beginning of a series of experimental solar array wing upgrades.

[11][12] The 1 February spacewalk, begun at 12:56 UTC and lasting 5 hours and 20 minutes, was conducted by Hopkins and Glover to conclude a four-year campaign, initiated by Shane Kimbrough and Peggy Whitson on Expedition 50, to replace the batteries on the Integrated Truss Structure.

[15][16][11] The 28 February spacewalk, begun at 11:12 UTC and lasting 7 hours and 4 minutes, was conducted by Rubins and Glover to install on the P6 Truss brackets for the experimental solar array upgrades, the main materials for which launched in June 2021 aboard SpaceX CRS-22.

[1][2][3][4] They had also initially planned to deploy a new airlock cover to strengthen Quest, replace a wireless video transceiver on the Unity node, route more cables on Bartolomeo, and vent and rearrange ammonia hoses.