Updates from the 550 included a redesigned interior as well as a number of mechanical improvements, including bigger brake discs, a larger and more powerful engine, improved weight distribution, refined aerodynamics and fluid-dynamics along with an adaptive suspension set-up (the four independent suspensions are also controlled by the gearbox, to minimize pitch throughout the 200-milliseconds shift time).

Introduced in 2005, the Ferrari Superamerica was a convertible version of the 575M Maranello; it featured an electrochromic glass panel roof which rotated 180° at the rear to lie flat over the boot taking 60 seconds for operation.

The Superamerica used the higher-output tune of the V12 engine used on the 575M, codenamed the F133 G, rated at 540 PS (397 kW; 533 hp) and Ferrari marketed it as the world's fastest convertible car, with a top speed of 320 km/h (199 mph).

[7] Total production amounted to 559 units; this number followed Enzo Ferrari's philosophy that there should always be one fewer car available than what the market demanded;[7] only 43 of those had a manual gearbox.

A special 575M was built by Zagato for Japanese Ferrari collector Yoshiyuki Hayashi, and announced at the 2006 Geneva Motor Show.

Introduced at the 2003 Frankfurt Motor Show, the 575 GTC was a modified 575M specially developed for the FIA GT Championship in collaboration with N Technology.

The increase in power was achieved by installing new camshafts and using a Magneti Marelli fuel injection system in place of the Bosch Motronic unit.