In the Ferrari Enzo, it set the record for the most powerful naturally aspirated engine in a road car.

The 5998.8 cc engine, designed for the Enzo, is known within Ferrari as the Tipo F140B, whereas the very similar Tipo F140C engine displaces 5998.8 cc and was designed for the 599 as the most powerful series-production Ferrari engine, a trend that has continued with the F12 and 812.

For Tipo F140EB displacement was enlarged to 6262.456 cc and debuted in FF.

The latest enlargement is the Tipo F140GA at 6495.6 cc used in the Ferrari 812 Superfast.

In 2018 the 812 Superfast powerplant was recognised as "Best New Engine" and gave Ferrari another "Above 4.0 litre" class win.