The 1954–55 season saw the Buffs make the NCAA tournament, though they would lose to eventual national champion San Francisco University.

From WTAMU Record Book:[2] The Lady Buff volleyball team is a four-time NCAA Division II National Champion, winning the title in 1990, 1991, 1997, and most recently in 2022.

[citation needed] The team plays its home matches at Britkare Court at the WTAMU Fieldhouse aka “The Box.” The Buffaloes and the Lady Buffs are one of the few Division II institutions that has an on campus cross country course, known as "The Range."

The Buffaloes have had 3 NCAA DII All-Americans, Geoffrey Kipchumba(2015,2016), Owen Hind (2017), and Briggs Wittlake (2018).

West Texas A&M Women's Outdoor Track & Field won the 2017 and 2022 National Championships defeating Grand Valley State each time in three day events.

The West Texas A&M Lady Buffs softball team Won the National Championship in 2014 defeating Valdosta State.