It originates at 30°44′28″N 87°47′56″W / 30.74102°N 87.79888°W / 30.74102; -87.79888, near Stapleton, and discharges into Weeks Bay at 30°24′49″N 87°49′31″W / 30.41353°N 87.82526°W / 30.41353; -87.82526 in Magnolia Springs.

[2] It was named by the original French colonists as the Riviere Aux Poissons,[2] which can be translated into English as Fish River.

The eagles were wiped out in Alabama but have made a comeback including nests along the river.

Occasionally grass shrimp are found in the river which is considered excellent bait for fishing.

[7] Fish River is part of the tidal system associated with Mobile Bay.