Fisher Run is a tributary of Catawissa Creek in Columbia County, Pennsylvania, in the United States.

Immediately after crossing Iron Bridge Road, the stream turns southeast and enters Beaver Township.

[1] Fisher Run joins Catawissa Creek 8.78 miles (14.13 km) upstream of its mouth.

[3] The upper reaches and most of the rest of the watershed of Fisher Run are in Pennsylvania State Game Lands Number 58.

[6] The Pennsylvania Department of Environmental Protection considers Fisher Run to be a high-quality coldwater fishery.

[3] It is also considered by the Pennsylvania Fish and Boat Commission to be Class A Wild Trout Waters between its headwaters and its mouth.