Mine Gap Run is a tributary of Catawissa Creek in Columbia County, Pennsylvania, in the United States.

Mine Gap Run begins on Catawissa Mountain in Roaring Creek Township.

[1][2] It crosses Mine Gap Road within a few hundred feet of its source and flows northeast in a valley for some distance.

[1] Mine Gap Run joins Catawissa Creek 9.12 miles (14.68 km) upstream of its mouth.

[1] The lower reaches of Mine Gap Run are on rock of the Mauch Chunk Formation.

[4] Mine Gap Run has a high gradient of 69.2 metres (227 ft) per kilometer (0.6 miles).

[5] The Pennsylvania Department of Environmental Protection considers Mine Gap Run to be a cold water fishery.