Antibody responses against proteins are believed to involve follicular B cell pathways in secondary lymphoid organs.
[1] Mature B cells from the spleen can be divided into two main populations: FO B cells, which constitute the majority, and marginal zone B-cells, lining outside the marginal sinus and bordering the red pulp.
Multiphoton-based live imaging of lymph nodes indicate continuous movement of FO B cells within these follicular areas at velocities of ~6 μm per min.
[2] Recent studies indicate movement along the processes of FDC as a guidance system for mature resting B cells in peripheral lymph nodes.
The BCR repertoire of the follicular B cell compartment also appears under positive selection pressures during final maturation in the spleen.