Fort Pitt Boulevard is a road in Pittsburgh on the southern area of Downtown, connecting Fort Pitt Bridge and Interstate 376.

Fort Pitt poses a particular challenge to both mapmaker and navigator—along its entire half-mile length, up to six separate roadways making up the Boulevard, the Penn-Lincoln Parkway, and ramps between the latter and various Downtown streets are woven together in a space less than 300 feet wide.

In 1806, it was the home of industrialist James O'Hara;[1] from 1840 to 1935 it was the site of Monongahela House, a hotel which played host to visitors such as Abraham Lincoln and Mark Twain.

[2] Of all the businesses that were established along the road prior to the name change, the only ones still in business are Heyl & Patterson Inc., W.W. Patterson Manufacturing and Graybar Electric Company.

Various maps and photographs, and a short history of the road, can be seen at Bridges and Tunnels of Allegheny County and Pittsburgh, Pennsylvania.