Running south from the Allegheny River to the Monongahela River, it is the western terminus of Forbes Avenue, and intersects 8 other streets.

Both of those former streets date back to the original town plan of 1784.

Fifth Street was renamed Stanwix Street in 1910 in honor of British General John Stanwix, who led the construction of Fort Pitt.

[1] The Great Fire of Pittsburgh of April 10, 1845, began on Ferry Street, which is now the southern portion of Stanwix Street.

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