In the early 2020s, both the boys and girls FZS soccer teams won multiple state championships.

[5] The Fort Zumwalt South Bulldogs won the Missouri State Championship in cross country in 2005[6] and 2006.

[7][8] In 2009, Fort Zumwalt South won the class 4 Missouri State Championship in baseball.

[9] In May 2012, the South High boys volleyball team won the Class 3 Missouri State Championship.

[10] In February 2013 and February 2014, South High's science bowl team won the regional competition allowing them to represent Missouri at the National Science Bowl competition in Washington D.C.[11] In 2018, 2020, and 2021 the boys varsity soccer team won the Class 3 Missouri State Championship.