Fortaleza San Luis is located near the Yaque del Norte River in southwest Santiago de los Caballeros, Dominican Republic.

The fort, throughout its history has been vital to the protection and control of the Dominican Republic's second city, Santiago, and by extension the entire Cibao Valley region.

As such, Spain sent 4 infantries under the command of Colonel Ramon de Portal y Santo Domingo to occupy the fort.

After the restoration of the Republic, the fort was converted into a military school, which in 1875, graduated its first class of Cadets from Officers Training in the Yaque Battalion.

In 1886, President Ulises Heureaux gave as a gift to Santiago de los Caballeros a clock tower that was installed in the Fortaleza San Luis.