In her work, she promotes the integration of science and technology into foreign policy dialogues; global scientific engagement for capacity-building; the advancement of women in STEM; and the use of innovation as a tool for economic growth around the world.

[1] Previously, Dr. Colón served the U.S. Department of State as the Science and Environment Adviser at the Western Hemisphere Affairs Bureau where she was responsible for advising on environmental and scientific issues that affected the U.S. Government's foreign policy objectives in the Americas.

[1] In November 2020, Colón was named a volunteer member of the Joe Biden presidential transition Agency Review Team to support transition efforts related to the United States Department of State.

[6] During her time as Deputy Adviser, she oversaw the creation of the Networks of Diasporas in Engineering and Science (NODES) initiative to empower diasporas with science expertise to develop and influence effective policies and solve challenges in their countries of origin.

[12][4] As part of President Obama's White House "Untold History of Women in STEM" project, she shared the story of Puerto Rican scientist Ana Roqué de Duprey.