Francis Higbee Case (December 9, 1896 – June 22, 1962) was an American journalist and politician who served for 25 years as a member of the United States Congress from South Dakota.

Case entered politics in 1934 when he ran for a seat in the United States House of Representatives but lost.

Before the United States entered World War II, he was a moderate supporter of isolationism.

Case decided to run for the Senate in the 1950 election, and defeated the incumbent John Chandler Gurney in the Republican primary.

Case was reelected to the Senate in 1956, in a very close race against Democrat Kenneth Holum, receiving 50.8% of the vote.

Case was known as a moderate senator whose main goals were to expand America's road and waterway infrastructure, particularly in South Dakota.