The Francis M. Kirkham House is a historic building located in Des Moines, Iowa, United States.

It features a hipped roof with gablets, decorative wood shingles in the gable end, bargeboards, reeded panels that form the cornice, a gabled bay placed at an angle, bracketed eaves, and decorative window surrounds.

The property on which it stands is a part of one of ten plats that were owned by Drake University.

Its significance is attributed to the effect of the University's innovative financing techniques upon the settlement of the area around the campus.

This article about a property in Polk County, Iowa on the National Register of Historic Places is a stub.