Lord and William V. Wilcox House is a historic building located in Des Moines, Iowa, United States.

This 2½-story dwelling follows a crossed gable plan that features elements of both the Colonial Revival and Queen Anne styles.

The property on which it stands is one of ten plats that were owned by Drake University.

The house's significance is attributed to the effect of the university's innovative financing techniques upon the settlement of the area around the campus.

This article about a property in Polk County, Iowa on the National Register of Historic Places is a stub.