The Nellie and Thomas Knotts House is a historic building located in Des Moines, Iowa, United States.

This two-story dwelling is a gabled-ell type house that features a chamfered front section with gable-end detail, fishscale shingles, and a hipped porch.

Nellie J. and Thomas H. Knotts acquired the property in 1893, and the house was built the following year.

Its significance is attributed to the effect of the University's innovative financing techniques upon the settlement of the area around the campus.

This article about a property in Polk County, Iowa on the National Register of Historic Places is a stub.