Chamberlain House and Wesley Acres, is a historic building located in Des Moines, Iowa, United States.

Designed by Boston architect William George Rantoul, it is considered an excellent example of Jacobethan Revival architecture in the city.

[3] It features five gables and dormers on the main facade that rise above the ridged roofline and three tall chimneys with separate shafts for each flue.

[3][4] David S. Chamberlain moved his patent medicine business[5] to Des Moines in 1881, and it grew to become one of the five largest pharmaceutical and toiletry manufacturing firms in the United States.

This article about a property in Polk County, Iowa on the National Register of Historic Places is a stub.