[4] In 2003, Tsai joined High Moon Studios where he was principal concept artist for the video games The Bourne Conspiracy and Darkwatch.

[11] In a generally favorable review of the novel, Martha Cornog wrote, "Francis Tsai's and Amelia Woo's painted art, especially their beautiful wolf depictions, make this all visually believable.

[13] Tsai provided interior artwork for a number of Dungeons & Dragons manuals for Wizards of the Coast, including Sharn: City of Towers, Monster Manual III, d20 Future, Races of Eberron, Lost Empires of Faerûn, Explorer's Handbook, Tome of Magic: Pact, Shadow, and Truename Magic, Power of Faerûn, Drow of the Underdark, and d20 Future Tech.

[18] Tsai worked on Tracker, a miniseries from Top Cow Productions and Heroes and Villains Entertainment about an FBI agent who has contracted a virus that turns him into a werewolf.

He was a regular contributor to ImagineFX magazine, where he has created a series of workshops including topics such as using 3-D in 2-D, effective character design and game concept art.