Frank Albert Sedita (June 20, 1907 – May 2, 1975) was an American attorney and politician who served as the 56th and 58th mayor of Buffalo, New York.

He attended Hutchinson Central High School and spent his summers working in canning factories and on farms in Wilson and Lyndonville, New York.

In June 1967, during the Buffalo riot at the Michigan Avenue YMCA, the mayor faced an angry crowd of young African Americans during an East Side street confrontation.

Because of health concerns, on February 8, 1973 Sedita submitted a letter of resignation to the Buffalo Common Council, to become effective on March 5, 1973.

His grandson, Frank A. Sedita III, was twice elected District Attorney of Erie County and is now a judge on the New York State Supreme Court.