Isaac R. Harrington (December 7, 1789 - August 20, 1851) was a prominent businessman and entrepreneur in Burlington, Vermont and Buffalo, New York.

[7] Harrington became active in several business ventures in Burlington, including a store where he sold dry goods, groceries, hardware and housewares.

[13] Another early Isaac Harrington business venture was operating the Phoenix, a Lake Champlain steamship which made regular trips to and from Whitehall, New York and Saint-Jean-sur-Richelieu, Quebec.

[16] In addition to Harrington's business career in Buffalo, he became active in the city's local government.

[17] In the mid-1830s, he was appointed to several commissions that assessed property owners in order to finance improvements to several Buffalo streets.

[25][27] Among the initiatives Harrington undertook as mayor was an effort to persuade New York's state government to fund improvements to the Erie Canal, which were intended to ensure that Buffalo-area shipping could continue during periods when the water level of Lake Erie receded.

[30] Taylor won and Harrington was one of the honorary managers of a February 1849 Whig inaugural ball held in Buffalo.

[30] Harrington's support for the Whig Party was recognized in May 1849, when he was appointed as postmaster of Buffalo, succeeding Henry K.