Lewis P. Dayton (1821 – May 14, 1900) was Mayor of the City of Buffalo, New York, serving from 1874 to 1875.

[2] He studied medicine in the office of Dr. Timothy T. Lockwood and moved to Buffalo.

In 1868, Dayton was appointed to the first Board of Park Commissioners and was chosen health physician for the City in 1871.

Dayton first remarried Mrs. Alice Maud Hayes (1842–1873), who died about a year after their marriage, then in 1892, he married Margaret Vogt (1855–1930).

[3] He was the father of four children, including: He died on May 14, 1900, and was buried in Forest Lawn Cemetery His brain was preserved in alcohol, possibly for medical research.