[1] In this form it is usually accumulated in the liver until it undergoes further conversion by aldolase B (the rate limiting enzyme of fructose metabolism).

Metabolism of fructose thus essentially results in intermediates of glycolysis.

The final product of glycolysis (pyruvate) may then undergo gluconeogenesis, enter the TCA cycle or be stored as fatty acids.

It depletes intracellular phosphate reserves which leads to loss of ATP and inhibition of biosynthetic pathways.

Symptoms of hereditary fructose intolerance are apathy, drowsiness, sweatiness and tremulousness.