[7] Abnormal regulation and expression of GSK-3 beta is associated with an increased susceptibility towards bipolar disorder.

Two isoforms, alpha (GSK3A) and beta, show a high degree of amino acid homology.

[5] GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.

Homozygous disruption of the Gsk3b locus in mice results in embryonic lethality during mid-gestation.

[11] Pharmacological inhibition of ERK1/2 restores GSK-3 beta activity and protein synthesis levels in a model of tuberous sclerosis.