3UVJ, 4NI2298260596ENSG00000164116ENSMUSG00000033910Q02108Q6PJR4Q9ERL9NM_001130686NM_001130687NM_001256449NM_021896NM_001356987NM_001356988NP_001124159NP_001243378NP_001366595NP_001366596NP_001366597NP_001366598NP_001366599NP_001366600NP_001366601NP_001366602NP_001366603NP_001366604NP_001366605NP_068696NP_001343916NP_001343917Guanylate cyclase soluble subunit alpha-3 is an enzyme that in humans is encoded by the GUCY1A3 gene.

[5][6] Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.

[6] Mutations in this gene have been associated to cases of myocardial infarction (10.1038/nature12722).

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