2WZ1, 3UVJ, 4NI2298354195ENSG00000061918ENSMUSG00000028005Q02153O54865NM_001291955NM_001161796NM_017469NP_001278884NP_001155268NP_059497Guanylate cyclase soluble subunit beta-1 is an enzyme that in humans is encoded by the GUCY1B3 gene.

[5][6] Soluble guanylate cyclase (sGC), a heterodimeric protein consisting of an alpha and a beta subunit, catalyzes the conversion of GTP to the second messenger cGMP and functions as the main receptor for nitric oxide and nitrovasodilator drugs.

[6] GUCY1B3 has been shown to interact with Heat shock protein 90kDa alpha (cytosolic), member A1[7] and Endothelial NOS.

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