These evidences from a genetic perspective agree with a large body of archaeological, anthropological, and linguistic conclusions that Native American peoples' ancestors migrated from Asia across a land bridge at the latest 16,500–13,000 years ago.
Indigenous peoples of the Americas have been linked to Siberian populations by linguistic factors, the distribution of blood types, and in genetic composition as reflected by molecular data, such as DNA.
Mormon researchers such as anthropologist Thomas W. Murphy and ex-Mormon plant geneticist Simon Southerton state that the substantial collection of Native American genetic markers now available are not consistent with any detectable presence of ancestors from the ancient Middle East.
[23][24][25] An introductory paragraph added to the Book of Mormon in the LDS Church's 1981 edition stated in part: "After thousands of years, all were destroyed except the Lamanites, and they are the principal ancestors of the American Indians.
[33] Michael F. Whiting, director of Brigham Young University's DNA Sequencing Center and an associate professor in BYU's Department of Integrative Biology, contests that, "given the complexities of genetic drift, founder effect, and introgression, the observation that Native Americans have a preponderance of Asian genes does not conclusively demonstrate that they are therefore not descendants of the Lamanite lineage, because we do not know what genetic signature that Lamanite lineage possessed at the conclusion of the Book of Mormon record."
and that, "[t]here are some very good scientific reasons for why the Book of Mormon is neither easily corroborated nor refuted by DNA evidence" [30] In November 2013 Nature published a discovery on an Upper Paleolithic Siberian site linking Western Eurasians in the Middle East and Europe to the indigenous Native American population.
[34][35][36][37] According to the study the genomes sequenced show distinct genetic markers that are unique to the indigenous Native Americans and western Eurasia, but with no relation to East Asians.
First, it shows that Upper Paleolithic Siberians came from a cosmopolitan population of early modern humans that spread out of Africa to Europe and Central and South Asia.
Second, Paleoindian skeletons like Buhl Woman with phenotypic traits atypical of modern-day indigenous Americans can be explained as having a direct historical connection to Upper Paleolithic Siberia.Book of Mormon defenders have responded to the article with reservation.
[38] While the descendants of Lehi would carry similar genetic markers, defenders have pointed out that the genome would have already been in the Western Hemisphere far earlier than the Book of Mormon claims.