The game was reworked into a PlayStation Portable version titled 50 Cent: Bulletproof G Unit Edition, with a top-down perspective, which released in 2006.

The story revolves around protagonist hip hop musician 50 Cent's search for vengeance against the hitmen who attempted to murder him.

50 Cent: Bulletproof gameplay is linear and focused on third person shooting, with use of a cover system, while promoting a run and gun play style, all taking place in an open world with individually designed levels or arenas.

[1] 50 Cent receives a distress call from his former juvie cellmate and friend K-Dog (Dwayne Adway), and assembles his crew - Lloyd Banks, Young Buck and Tony Yayo – to help him.

50’s crew brings him to the apartment of Doc Friday, a former licensed doctor until he started writing prescriptions for himself, to recover for a few weeks.

50 Cent brings K-Dog’s phone to Bugs, a wheelchair-bound pawn shop owner and hacker, and they find a voicemail from biker leader Spider about them meeting.

When 50 Cent rides the subway back to Queens, the tactical squad storms the train, having traced K-Dog’s phone to 50’s location.

Booker (Chad L. Coleman), a homeless man that 50 Cent had befriended in recent months, warns him that Spinoza survived their subway encounter and came by his apartment building asking about him.

Booker, a Coast Guard veteran, also helps 50 make sense of the shipping documents he took from Spider, which lead to a dockside warehouse.

McVicar explains to 50 that Spinoza is probably the person that initially shot him nine times, and discovers that Eduardo Vasquez is a deceased drug mule currently in a Midtown Manhattan morgue.

50 is rescued from a chainsaw executioner by Grizz (Dr. Dre), his longtime arms dealer, and they kill every mobster on site to find out that the informant was Capidilupo himself.

50 Cent, Bugs and McVicar listen to the tape from Capidilupo’s wiretap, and hear him meeting with Spinoza (Nolan North) along with Muqtada Muhammad, a Saudi embassy official with ties to oil money and terrorism.

While the story and cutscenes are the same as the console counterpart, the game eschews the third-person perspective game-play for a top-down, isometric viewpoint.

The PlayStation Portable version featured a "Vitamin Water" minigame in which the player plays as 50 Cent at the apex of his business endeavors.

[4] Consumers who pre-ordered the album were also given a previously unreleased DVD of 50 Cent's 2003 European tour called "No Fear, No Mercy".

[45][46] 50 Cent: Bulletproof sold 1,123,000 units, according to NPD Group (it is unclear whether this figure includes the PSP's "G-Unit Edition" release).