[1][2] He grew up with his older brother, Chris Humes, a former cornerback for the Arkansas Razorbacks and later the Oakland Raiders of the NFL, who is seven years his senior.

The catch is what put Georgia in Alabama territory for the first time during the game, setting up a short field goal for the Bulldogs.

[22] In Week 3 against the Cleveland Browns, Pickens corralled a one-handed catch while fully extending his body in the air.

[24] Pickens scored his first professional touchdown during primetime in Week 7 against the Miami Dolphins when he caught a seven-yard pass from quarterback Kenny Pickett.

"[35] During Week 15 against the Indianapolis Colts, Pickens was again criticized for a lack of effort, most notably not blocking for running back Jaylen Warren on a potential touchdown drive near the goal line.

[39] Pickens would eclipse his first 100 receiving yard game of the season during the team's Week 4 24–27 loss to the Indianapolis Colts.

The Steelers needed to gain significant yardage with no timeouts remaining to put themselves in field goal range to tie the score.

Pickens caught the ball around the 25 yard line and stood in place momentarily before throwing a backwards pass to Isaac Seumalo leading to multiple lateral passes being thrown before time expired with a failed lateral from Pat Freiermuth to Mason McCormick to end the game.

His only catch was at the line of scrimmage resulting in him having his only zero yard game of his career thus far as the Steelers were narrowly defeated by the Bengals 19-17.

[53] After being drafted by the Steelers in 2022, Pickens moved into an apartment in Pittsburgh with his older brother, Chris Humes.

[54] In 2023, Pickens spent Thanksgiving with teammate Broderick Jones at head coach Mike Tomlin's home.

Dressed in a white T-shirt, blue basketball shorts, and a ski mask, commonly called a "sheisty," Pickens watched as he was selected by the Pittsburgh Steelers in the second round from his family's living room.

He told CBS Sports he decided to take a more relaxed approach to Day 2, skipping the formal suit he had prepared for the draft's opening night.