George Rex Graham (January 18, 1813 – July 13, 1894) was an American magazine editor and publisher from Philadelphia, Pennsylvania.

Graham worked with many notable literary figures including Edgar Allan Poe and Rufus Wilmot Griswold, and possibly sparked the enmity between the two.

Graham was raised by his namesake and maternal uncle, George Rex, a farmer from Montgomery County, Pennsylvania.

[2] Graham first began his publishing work with an editorial position with the Saturday Evening Post and later became the proprietor of Atkinson's Casket.

Success was partially owed by Graham's willingness to include brand new engravings and illustrations at a time when most monthly publications were re-using old plates from other magazines.

[6] Graham's Magazine was the first to publish many of Poe's works, including "The Murders in the Rue Morgue" and "The Colloquy of Monos and Una".

[11] However, competition with Harper's New Monthly Magazine caused significant drops in subscriptions, as did the lack of an international copyright.

He was assisted financially by George William Childs before dying on July 13, 1894, at a hospital in Orange, New Jersey.