It runs southwest-to-northeast in an arc through portions of Macon and Houston counties.

Just before entering Perry, it meets SR 127 (Marshallville Road).

Shortly after, SR 224 departs to the southeast, while US 41/SR 7/SR 127 head to the northeast into downtown Perry on General Courtney Hodges Boulevard.

The highway heads southeast through rural areas until it meets its eastern terminus, an intersection with US 341/SR 11 (Main Street) southeast of Perry.

[1] SR 224 is not part of the National Highway System, a system of roadways important to the nation's economy, defense, and mobility.