The road heads to the east, passing the Thomasville Regional Airport, and travels through rural areas of the county until it reaches the town of Pavo.

It intersects SR 125 (Bemiss Road/Valdosta Ray City Highway) at the meeting point of Lowndes, Berrien, and Lanier counties.

The highway parallels most of the northern part of Banks Lake, and intersects SR 122 Connector, prior to entering Lakeland.

At Oak Street, SR 135 Bypass joins the concurrency for a short while.

SR 122 heads east until it meets an intersection with US 1/US 23/US 82/SR 4/SR 520 (South Georgia Parkway), west of Waycross.

The highway continues to the northwest until it meets its northern terminus, an intersection US 129/SR 11/SR 37.